Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy

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Knežević, Nikola Ž. | Mrđanović, Jasminka | Borišev, Ivana | Milenković, Sanja | Janaćković, Đorđe | Cunin, Frédérique | Djordjevic, Aleksandar

Edité par CCSD ; Royal Society of Chemistry -

International audience. A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-overexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.

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