The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics

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Daurat, Morgane | Nguyen, Christophe | Dominguez Gil, Sofia | Sol, Vincent | Chaleix, Vincent | Charnay, Clarence | Raehm, Laurence | El Cheikh, Khaled | Morère, Alain | Bernasconi, Michele | Timpanaro, Andrea | Garcia, Marcel | Cunin, Frédérique | Roessler, Jochen | Durand, Jean-Olivier | Gary-Bobo, Magali

Edité par CCSD ; Royal Society of Chemistry (RSC) -

International audience. Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO–AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed

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