Ruthenium(II) Complex-Photosensitized Multifunctionalized Porous Silicon Nanoparticles for Two-Photon Near-Infrared Light Responsive Imaging and Photodynamic Cancer Therapy

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Knežević, Nikola Ž. | Stojanovic, Vanja | Chaix, Arnaud | Bouffard, Elise | Cheikh, Khaled El | Morère, Alain | Maynadier, Marie | Lemercier, Gilles | Garcia, Marcel | Gary-Bobo, Magali | Durand, Jean-Olivier | Cunin, Frédérique

Edité par CCSD ; Royal Society of Chemistry -

International audience. Multifunctionalized porous silicon nanoparticles (pSiNP) containing novel Ru(II) complex-photosensitizer, polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to twophoton excitation of the Ru(II)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers.

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