TADs or no TADS: Lessons From Single-cell Imaging of Chromosome Architecture

Archive ouverte | Gizzi, Andrés M Cardozo | CCSD

International audience. Eukaryotic genomes are folded in a hierarchical organization that reflects and possibly regulates their function. Genomewide studies revealed a new level of organization at the kilobase-to-me...

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Archive ouverte | Cattoni, Diego | CCSD

International audience. At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that associate to form nuclear compartments. ...

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during development

Archive ouverte | Espinola, Sergio, Martin | CCSD