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pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

Archive ouverte | Devos, Xavier | CCSD

International audience. Genome-wide ensemble sequencing methods improved our understanding of chromatin organization in eukaryotes but lack the ability to capture single-cell heterogeneity and spatial organization. ...

Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms

Archive ouverte | Cardozo Gizzi, Andres | CCSD

Eukaryotic chromosomes are organized in multiple scales, from nucleosomes to chromosome territories. Recently, genome-wide methods identified an intermediate level of chromosome organization, topologically associating domains (TAD...

Multiple parameters shape the 3D chromatin structure of single nuclei

Archive ouverte | Götz, Markus | CCSD

International audience. Abstract The spatial organization of chromatin at the scale of topologically associating domains (TADs) and below displays large cell-to-cell variations. Up until now, how this heterogeneity ...

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