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ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

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Ma, Yuting | Adjemian, Sandy | Yang, Heng | Portela Catani, Joao Paulo | Hannani, Dalil | Martins, Isabelle | Michaud, Mickaël | Kepp, Oliver | Qader Sukkurwala, Abdul | Vacchelli, Erika | Galluzzi, Lorenzo | Zitvogel, Laurence | Kroemer, Guido

Edité par CCSD ; Taylor & Francis -

International audience. Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens.

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