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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

Archive ouverte | Ma, Yuting | CCSD

International audience. The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to ...

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Archive ouverte | Sistigu, Antonella | CCSD

International audience. The immune system is routinely confronted with cell death resulting from the physiological turnover of renewable tissues, as well as from pathological insults of several types. We hypothesize...

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

Archive ouverte | Ma, Yuting | CCSD

International audience. Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the p...

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