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Histone Deacetylase Inhibitors Induce Premature Sister Chromatid Separation and Override the Mitotic Spindle Assembly Checkpoint

Archive ouverte | Magnaghi-Jaulin, Laura | CCSD

International audience. Abstract Histone deacetylase inhibitors (HDACI) are powerful antiproliferative drugs, and are currently undergoing clinical trials as antitumor agents. It would be valuable for both cancer th...

Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion

Archive ouverte | Eot-Houllier, Grégory | CCSD

International audience. We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere. HDAC3 knockdown induced spindle ass...

Histone deacetylase inhibitors and genomic instability.

Archive ouverte | Eot-Houllier, Grégory | CCSD

International audience. Histone deacetylase inhibitors (HDACIs) are a promising new class of anticancer drugs. However, their mechanism of action has not been fully elucidated. Most studies have investigated the eff...

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