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Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

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Pochet, Sylvie | Dugué, Laurence | Douguet, Dominique | Labesse, Gilles | Munier-Lehmann, Hélène

Edité par CCSD ; Wiley-VCH Verlag -

International audience. Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs. A modeling and docking study was used to rationalize the experimental data.

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