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Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Archive ouverte | Pochet, Sylvie | CCSD

International audience. Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs....

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

Archive ouverte | Pochet, Sylvie | CCSD

Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine pathway and of unique structura...

Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound

Archive ouverte | Gelin, Muriel | CCSD

International audience. Making new ligands for a given protein by in situ ligation of building blocks (or fragments) is an attractive method. However, it suffers from inherent limitations, such as the limited number...

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