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Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures

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Zhou, Jun | Korkut, Dursun Nizam | Rosu, Frédéric | Amrane, Samir | Gabelica, Valérie | Mergny, Jean-Louis

Edité par CCSD ; Elsevier -

International audience. In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications. We hope this paper will guide others as they perform similar experiments leading to more information about the effects of chemical modifications on G-quadruplex formation. The structures of tetramolecular quadruplexes and some higher order structures based on tetramolecular quadruplexes are also described.

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