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G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

Archive ouverte | Belmonte-Reche, Efres | CCSD

International audience. G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and v...

Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity

Archive ouverte | Belmonte-Reche, Efres | CCSD

International audience. Glycosyl conjugation to drugs is a strategy being used to take advantage of glucose transporters (GLUT) overexpression in cancer cells in comparison with non-cancerous cells. Its extension to...

Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures

Archive ouverte | Zhou, Jun | CCSD

International audience. In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modi...

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