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The Blood of Healthy Individuals Exhibits CD8 T Cells with a Highly Altered TCR Vb Repertoire but with an Unmodified Phenotype

Archive ouverte | Degauque, Nicolas | CCSD

International audience. CD8 T cell clonal expansions (TCE) have been observed in elderly, healthy individuals as well in old mice, and have been associated with the ageing process. Both chronic latent and non-persis...

A phenotypic, transcriptional and TCR Vβ repertoire signature of CD8+ T cells define a population at-risk of long-term kidney graft dysfunction

Archive ouverte | Degauque, Nicolas | CCSD

International audience

Expansion of Highly Differentiated Cytotoxic Terminally Differentiated Effector Memory CD8+ T Cells in a Subset of Clinically Stable Kidney Transplant Recipients: A Potential Marker for Late Graft Dysfunction

Archive ouverte | Yap, Michelle | CCSD

S.B. and N.D. contributed equally to this work.. International audience. Despite the effectiveness of immunosuppressive drugs, kidney transplant recipients still face late graft dysfunction. Thus, it is necessary to...

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