The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

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The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

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Kuchroo, Juhi | Hafler, David | Sharpe, Arlene | Lucca, Liliana, E

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

International audience. PD-1 restrains both effector T cells and T regs ; therefore, PD-1 may be uniquely modulated to enhance tumor rejection while maintaining immune tolerance.

Langue: en

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