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Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

Archive ouverte | Lucca, Liliana, E | CCSD

International audience. Understanding the relationship between tumor and peripheral immune environments could allow longitudinal immune monitoring in cancer. Here, we examined whether T cells that share the same TCR...

Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma

Archive ouverte | Lu, Benjamin | CCSD

International audience

The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

Archive ouverte | Kuchroo, Juhi | CCSD

International audience. PD-1 restrains both effector T cells and T regs ; therefore, PD-1 may be uniquely modulated to enhance tumor rejection while maintaining immune tolerance.

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