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Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression

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Vouilloz, Adrien | Bourgeois, Thibaut | Diedisheim, Marc | Pilot, Thomas | Jalil, Antoine | Le Guern, Naig | Bergas, Victoria | Rohmer, Noéline | Castelli, Florence | Leleu, Damien | Varin, Alexis | de Barros, Jean-Paul Pais | Degrace, Pascal | Rialland, Mickael | Blériot, Camille | Venteclef, Nicolas | Thomas, Charles | Masson, David

Edité par CCSD ; Elsevier -

International audience. Although qualitative and quantitative alterations in liver Polyunsaturated Fatty Acids (PUFAs) are observed in MASH in humans, a causal relationship of PUFAs biosynthetic pathways is yet to be clarified. ELOVL5, an essential enzyme in PUFA elongation regulates hepatic triglyceride metabolism. Nonetheless, the long-term consequences of elongase disruption, particularly in murine models of MASH, have not been evaluated.

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