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Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for Liver X receptors Oxysterols modulate glycolysis in human macrophages

Archive ouverte | Ménégaut, Louise | CCSD

International audience. Background and purpose: Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms as well as the pathophysiological sign...

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1a Potentiates Interleukin-1b Production in Human Macrophages

Archive ouverte | Ménégaut, Louise | CCSD

International audience. Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate of cardiovascular events. While cholesterol accumul...

Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression

Archive ouverte | Vouilloz, Adrien | CCSD

International audience. Although qualitative and quantitative alterations in liver Polyunsaturated Fatty Acids (PUFAs) are observed in MASH in humans, a causal relationship of PUFAs biosynthetic pathways is yet to b...

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