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Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

Archive ouverte | Mechling, Anna E. | CCSD

Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene's activity on whole-brain networks remains unknown. We tested whether the sole targeted dele...

Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice

Archive ouverte | Nasseef, Md Taufiq | CCSD

Mu opioid receptor (MOR) activation facilitates reward processing and reduces pain, and brain networks underlying these effects are under intense investigation. Mice lacking the MOR gene (MOR KO mice) show lower drug and social re...

Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice

Archive ouverte | Arefin, Tanzil Mahmud | CCSD

Recent studies have demonstrated that orchestrated gene activity and expression support synchronous activity of brain networks. However, there is a paucity of information on the consequences of single gene function on overall brai...

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