Functional role for the GIRK1/4, Cav1.3 and HCN4 channels in muscarinic regulation of heart rate

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Talssi, Leïla | Bidaud, Isabelle | Mangoni, Matteo, Elia | Mesirca, Pietro

Edité par CCSD -

International audience. Parasympathetic (cholinergic) stimulation slows the heart- rate (HR) by decreasing the spontaneous and non-invasively these abnormalities in the subclinicalstate.

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Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity

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International audience. Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the ubiquitously expressed cardiac voltage-gated L-type Cav1.2 Ca2+ channel isoform, pacemaker cells ...

Cholinergic regulation of cardiac pacemaker activity by l-type cav1.3 channels

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International audience. Introduction : The cholinergic regulation of heart rate (HR) is mediated by acetylcholine (ACh)-dependent activation of M2-receptors (M2R). Activated M2R promote release of the βγ-subunit of ...

Computational modelling of mouse atrio ventricular node action potential and automaticity

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International audience. The atrioventricular node (AVN) is a crucial component of the cardiac conduction system. Despite its pivotal role in regulating the transmission of electrical signals between atria and ventri...

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