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Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

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Fermier, Nicolas | Bourguignon, Laurent | Goutelle, Sylvain | Bleyzac, Nathalie | Tod, Michel

Edité par CCSD ; Springer Verlag -

International audience. The magnitude of drug-drug interactions mediated by cytochrome P450 (CYP) may depend on the genotype of polymorphic cytochromes. The objective of this study was to identify drug-drug interactions with greater magnitude in CYP variant groups than in extensive metabolizers.

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