The regenerative potential of autologous stem and somatic cells in vitiligo

Archive ouverte

Chanteloube, Sarah | Debret, Romain

Edité par CCSD ; John Libbey Eurotext -

International audience. Vitiligo is a human pigmentary disorder characterized by autoimmune destruction of mature melanocytes in the skin. In addition to researches on the inflammatory component of the disease, current treatments tend to stimulate local melanocyte stem cells or transplant functional melanocytes from uninjured areas. However, in some cases of extensive depigmentation, only few healthy cells can be obtained. This review discusses examples in the literature of using different sources of autologous stem and somatic cells to obtain melanocyte progenitors or mature melanocytes, and compares the strategy of stem cell differentiation with that of somatic cell reprogramming. More specifically, this review illustrates the differentiation capabilities of stem cells from dental pulp, bone marrow, and adipose tissue; the reprogramming of pluripotent cells, and the transdifferentiation of fibroblasts and keratinocytes. Each of these approaches is capable of producing fully functional melanocytes, but all have advantages and disadvantages. Finally, the relevance for potential clinical application is discussed, along with the risks associated with each strategy and the major current barriers to their use.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion