Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs

Archive ouverte

Gómez-Bouzó, Uxía | Belorusova, Anna | Rivadulla, Marcos, L | Santalla, Hugo | Verlinden, Lieve | Verstuyf, Annemieke | Ferronato, Maria, J | Curino, Alejandro, C | Facchinetti, Maria, M | Fall, Yagamare | Gómez, Generosa | Rochel, Natacha

Edité par CCSD ; Elsevier -

International audience. Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D 3. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D 3 with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediated biological effects similar to 1,25dihydroxyvitamin D 3 , the 25-amino derivative being the most potent one while being less calcemic than 1,25-dihydroxyvitamin D 3. The in vivo properties of the compounds make them of potential therapeutic value.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion