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Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain

Archive ouverte | Gómez-Bouzó, Uxía | CCSD

International audience. We synthesized two new gemini analogues UG-480 and UG-481 that incorporate a modified longer side chain containing a cyclopropane group. The evaluation of the bioactivities of the two gemini ...

Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs

Archive ouverte | Gómez-Bouzó, Uxía | CCSD

International audience. Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D 3. We describe here the structural analysis and biological evaluation of...

Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors

Archive ouverte | Gómez-Bouzó, Uxía | CCSD

International audience. Synthesis of six novel Gemini cholesterol analogues and the binding mode of one of them to RORγ.

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