ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy

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Bouzbib, Charlotte | El Mourabit, Haquima | Wendum, Dominique | Lasnier, Elisabeth | Mouri, Sarah | Housset, Chantal | Thabut, Dominique | Weiss, Nicolas | Rudler, Marika

Edité par CCSD ; Elsevier -

International audience. Background: Pathophysiology of acute encephalopathy in cirrhotic patients is not completely understood. Factors implicated include ammonia, inflammation, various metabolic disorders and drug toxicity. Recent studies have evidenced an increased permeability of the blood-brain barrier (BBB) in models of chronic liver disease and encephalopathy, either to solutes, or to leukocytes. A modification of the expression of BBB ATP-Binding Cassette (ABC) transporters, actively transporting endogenous and exogenous components through the BBB, has been

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