A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy

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Schaefer, Augustin | Journaux, Martin | Mourabit, Haquima, El | Mouri, Sarah | Wendum, Dominique | Lasnier, Elisabeth | Couraud, Pierre-Olivier | Housset, Chantal | Thabut, Dominique | Rudler, Marika | Weiss, Nicolas

Edité par CCSD ; Elsevier -

International audience. Background: Hepatic encephalopathy (HE) is a frequent neurological complication of cirrhosis. Evidence suggests a synergic pathophysiological implication of hyperammonemia and systemic inflammation. In addition, the blood-brain barrier (BBB) permeability can be impaired in cirrhotic patients, notably in those displaying HE. We hypothesized that systemic inflammation could trigger leukocytes transendothelial migration (TEM) through the BBB in cirrhotic patients and especially those with HE.

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