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Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors

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Pollastri, Sara | Delaunay, Clara | Thépaut, Michel | Fieschi, Franck | Bernardi, Anna

Edité par CCSD ; Royal Society of Chemistry -

International audience. The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The molecules described here are the first known glycomimetic ligands of L-SIGN.

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