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Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN

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Delaunay, Clara | Pollastri, Sara | Thépaut, Michel | Cavazzoli, Gianluca | Belvisi, Laura | Bouchikri, Clémentine | Labiod, Nuria | Lasala, Fatima | Gimeno, Ana | Franconetti, Antonio | Jiménez-Barbero, Jesús | Ardá, Ana | Delgado, Rafael | Bernardi, Anna | Fieschi, Franck

Edité par CCSD ; The Royal Society of Chemistry -

International audience. DC-SIGN and L-SIGN are C-type lectin receptors that act as viral coreceptors for SARS-CoV-2. Their distinct tissue localization justifies the search for a selective ligand for L-SIGN, despite their high homology suggesting the task hard to achieve.

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