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The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

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Goulet, Adeline | Behnke-Parks, William, M | Sindelar, Charles, V | Major, Jennifer | Rosenfeld, Steven, S | Moores, Carolyn, A

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Kinesin-5 motors are important for formation and maintenance of the bipolar mitotic spindle. Results: ATP binding triggers coupled conformational changes of kinesin-5 specific structural elements in the microtubulebound motor domain. Conclusion: Kinesin-5 mechanochemistry is tuned to its cellular functions. Significance: Subnanometer resolution structure determination of microtubule-bound kinesin-5s and kinetics experiments reveal the molecular basis of their motor properties and of drug inhibition.

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