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Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

Archive ouverte | Goulet, Adeline | CCSD

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The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

Archive ouverte | Goulet, Adeline | CCSD

International audience. Kinesin-5 motors are important for formation and maintenance of the bipolar mitotic spindle. Results: ATP binding triggers coupled conformational changes of kinesin-5 specific structural elem...

Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

Archive ouverte | Goulet, Adeline | CCSD

International audience. Cut7, the sole kinesin-5 in Schizosaccharomyces pombe , is essential for mitosis. Like other yeast kinesin-5 motors, Cut7 can reverse its stepping direction, by mechanisms that are currently ...

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