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Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation

Archive ouverte | Hosseini, Mohsen | CCSD

International audience. Graphical Abstract Highlights d Specific metabolic modifications precede UVB-induced primary tumor formation d DHODH fuels mitochondrial respiration to coordinate DNA repair and ATP synthesis...

UVB-induced DHODH upregulation, which is driven by STAT3, is a promising target for chemoprevention and combination therapy of photocarcinogenesis

Archive ouverte | Hosseini, Mohsen | CCSD

International audience

Energy metabolism rewiring following acute UVB irradiation is largely dependent on nuclear DNA damage

Archive ouverte | Dousset, Léa | CCSD

International audience. Solar ultraviolet B (UVB) radiation-induced DNA damage is a well-known initiator of skin carcinomas. The UVB-induced DNA damage response (DDR) involves series of signaling cascades that are a...

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