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Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation

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Hosseini, Mohsen | Dousset, Léa | Mahfouf, Walid | Serrano-Sanchez, Martin | Redonnet-Vernhet, Isabelle | Mesli, Samir | Kasraian, Zeinab | Obre, Emilie | Bonneu, Marc | Claverol, Stephane | Vlaski, Marija | Ivanovic, Zoran | Rachidi, Walid | Douki, Thierry | Taieb, Alain | Bouzier-Sore, Anne-Karine | Rossignol, Rodrigue | Rezvani, Hamid Reza

Edité par CCSD ; Elsevier Inc -

International audience. Graphical Abstract Highlights d Specific metabolic modifications precede UVB-induced primary tumor formation d DHODH fuels mitochondrial respiration to coordinate DNA repair and ATP synthesis d Respiration-linked nucleotide synthesis is necessary for primary skin tumor formation d Impairment of ETC blocks neoplastic transformation of keratinocytes In Brief Hosseini et al. show that specific metabolic modifications occur at a very early stage of photocarcinogenesis. Those modifications ensure the coordination of ATP generation, persistent nucleotide biosynthesis and repair of DNA damage, which all play an important role in defining of epidermal cell fate.

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