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Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

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Nathan, Nadia | Montagne, Marie-Emeline | Macchi, Odile | Rosental, Paul-André | Chauveau, Simon | Jeny, Florence | Sesé, Lucile | Abou Taam, Rola | Brocvielle, Manon | Brouard, Jacques | Catinon, Mickaël | Chapelon-Abric, Catherine | Cohen-Aubart, Fleur | Delacourt, Christophe | Delestrain, Céline | Deschildre, Antoine | Dossier, Antoine | Epaud, Ralph | Haroche, Julien | Houdouin, Véronique | Israel-Biet, Dominique | Juvin, Karine | Le Jeune, Sylvain | Lionnet, François | Meinzer, Ulrich | Mittaine, Marie | Nunes, Hilario | Mattioni, Sarah | Naccache, Jean-Marc | Odièvre, Marie-Hélène | Vincent, Michel | Clement, Annick | Valeyre, Dominique | Cavalin, Catherine

Edité par CCSD ; BMJ Publishing Group -

International audience. Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

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