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Child-Adult Transition in Sarcoidosis: A Series of 52 Patients.
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International audience. (1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very fewpediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution ofpediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with apediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in Frenchexpert centers were included. Clinical information at presentation and outcome in adulthood werestudied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration timeof follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease(84.5%), others within the three years after treatment interruption (9.1%), and rarely when the diseasewas stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood.Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median durationof five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverseevents. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.
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