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In vivo selection of lethal mutations reveals two functional domains in arginyl–tRNA synthetase

Archive ouverte | Geslain, Renaud | CCSD

Using random mutagenesis and a genetic screening in yeast, we isolated 26 mutations that inactivate Saccharomyces cerevisiae arginyl–tRNA synthetase (ArgRS). The mutations were identified and the kinetic parameters of the correspo...

L-Arginine recognition by yeast arginyl-tRNA synthetase

Archive ouverte | Cavarelli, Jean | CCSD

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Mutation and evolution of the magnesium-binding site of a class II aminoacyl-tRNA synthetase.

Archive ouverte | Ador, Laurent | CCSD

Aminoacyl-tRNA synthetases contain one or three Mg(2+) ions in their catalytic sites. In addition to their role in ATP binding, these ions are presumed to play a role in catalysis by increasing the electropositivity of the alpha-p...

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