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Decrypting Prion Protein Conversion into a β-Rich Conformer by Molecular Dynamics.

Archive ouverte | Chakroun, Nesrine | CCSD

International audience. Prion diseases are fatal neurodegenerative diseases characterized by the formation of β-rich oligomers and the accumulation of amyloid fibrillar deposits in the central nervous system. Unders...

The oligomerization properties of prion protein are restricted to the H2H3 domain.

Archive ouverte | Chakroun, Nesrine | CCSD

International audience. The propensity of the prion protein (PrP) to adopt different structures is a clue to its pathological behavior. The determination of the region involved in the PrP(C) to PrP(Sc) conversion is...

Probing the early stages of prion protein (PrP) aggregation with atomistic molecular dynamics simulations

Archive ouverte | Collu, Francesca | CCSD

International audience. Prions are self-replicating infectious proteinaceous agents whose conformations are capable of forming amyloid-like aggregate fibrils. Here we present molecular dynamics simulations aimed at ...

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