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Probing the early stages of prion protein (PrP) aggregation with atomistic molecular dynamics simulations

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Collu, Francesca | Spiga, Enrico | Chakroun, Nesrine | Rezaei, Human | Fraternali, Franca

Edité par CCSD ; Royal Society of Chemistry -

International audience. Prions are self-replicating infectious proteinaceous agents whose conformations are capable of forming amyloid-like aggregate fibrils. Here we present molecular dynamics simulations aimed at investigating the aggregation process of the -rich H2H3 domain of the ovine prion protein (H2H3-OvPrP(Sc)), known to be the portion of prion protein carrying oligomerization activity.

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