The anabolic effects of insulin-like growth factor-1 on skeletal growth and development: lessons from clinical and animal studies

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Courtland, Hayden-William | Elis, Sébastien | Yakar, Shoshana

Edité par CCSD -

International audience. Skeletal growth and maintenance is complex, involving developmental regulators and metabolic hormones. However, many case studies and a large number of investigations in rodents and other species have shown unequivocally that the growth hormone (GH)–insulin-like growth factor-1 (IGF-1) pathway is the major axis controlling linear skeletal growth.

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