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Elevated Serum Levels of IGF-1 Are Sufficient to Establish Normal Body Size and Skeletal Properties Even in the Absence of Tissue IGF-1

Archive ouverte | Elis, Sébastien | CCSD

International audience. Use of recombinant insulin-like growth factor 1 (IGF-1) as a treatment for primary IGF-1 deficiency in children has become increasingly common. When untreated, primary IGF-1 deficiency may le...

Depletion of serum IGF-1 after peak bone acquisition does not affect skeletal architecture in the adult mouse

Archive ouverte | Courtland, Hayden-William | CCSD

International audience

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression

Archive ouverte | Elis, Sébastien | CCSD

International audience. Although the literature suggests a protective (anabolic) effect of insulin-like growth factor-1 (IGF-1) on the musculoskeletal system during growth and aging, there is evidence that reduction...

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