Suggestions

Du même auteur

Synthesis and structure-activity relationship study of novel quinazolinone-based inhibitors of MurA

Archive ouverte | Hrast, Martina | CCSD

International audience. MurA is an intracellular bacterial enzyme that is essential for peptidoglycan biosynthesis, and is therefore an important target for antibacterial drug discovery. We report the synthesis, in ...

Discovery of new MurA inhibitors using induced-fit simulation and docking

Archive ouverte | Rožman, Kaja | CCSD

International audience. We report on the successful application of ProBiS-CHARMMing web server in the discovery of new inhibitors of MurA, an enzyme that catalyzes the first committed cytoplasmic step of bacterial p...

A road map for prioritizing warheads for cysteine targeting covalent inhibitors

Archive ouverte | Abranyi-Balogh, Peter | CCSD

WOS:000450383500008. International audience. Targeted covalent inhibitors have become an integral part of a number of therapeutic protocols and are the subject of intense research. The mechanism of action of these c...

Chargement des enrichissements...