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Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins

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Koubeissi, Ali | Raad, Imad | Ettouati, Laurent | Guilet, David | Dumontet, Charles | Paris, Joëlle

Edité par CCSD ; Elsevier -

International audience. — Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins.

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