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Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.

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Doyère, Valérie | Monfils, Marie-H. | Schafe, Glenn E. | Ledoux, Joseph E. | Debiec, Jacek

Edité par CCSD ; Nature Publishing Group -

International audience. When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.

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