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Cholesterol favors the anchorage of human dystrophin repeats 16 to 21 in membrane at physiological surface pressure.

Archive ouverte | Ameziane-Le Hir, Sarah | CCSD

International audience. Dystrophin (DYS) is a filamentous protein that connects the cytoskeleton and the extracellular matrix via the sarcolemma, conferring resistance to muscular cells. In this study, interactions ...

Role of the central domain of the Human dystrophin in sarcolemma scaffolding

Archive ouverte | Vié, V. | CCSD

International audience

Dystrophin Hot-Spot Mutants Leading to Becker Muscular Dystrophy Insert More Deeply into Membrane Models than the Native Protein

Archive ouverte | Ameziane-Le Hir, Sarah | CCSD

International audience. Dystrophin (DYS) is a membrane skeleton protein whose mutations lead to lethal Duchenne muscular dystrophy or to the milder Becker muscular dystrophy (BMD). One third of BMD "in-frame" exon d...

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