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Human dystrophin fragments interact with membrane models: role of the central domain on sarcolemma scaffolding and mechanical involvement

Archive ouverte | Ameziane-Le Hir, Sarah | CCSD

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Dystrophin Hot-Spot Mutants Leading to Becker Muscular Dystrophy Insert More Deeply into Membrane Models than the Native Protein

Archive ouverte | Ameziane-Le Hir, Sarah | CCSD

International audience. Dystrophin (DYS) is a membrane skeleton protein whose mutations lead to lethal Duchenne muscular dystrophy or to the milder Becker muscular dystrophy (BMD). One third of BMD "in-frame" exon d...

Cholesterol favors the anchorage of human dystrophin repeats 16 to 21 in membrane at physiological surface pressure.

Archive ouverte | Ameziane-Le Hir, Sarah | CCSD

International audience. Dystrophin (DYS) is a filamentous protein that connects the cytoskeleton and the extracellular matrix via the sarcolemma, conferring resistance to muscular cells. In this study, interactions ...

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