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Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses

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Bilal, Sueleyman | Haworth, Oliver | Wu, Lijun | Weylandt, Karsten H. | Levy, Bruce D. | Kang, Jing X.

Edité par CCSD ; Elsevier -

International audience. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been implicated in the alleviation of asthma. Recent studies have demonstrated that the n-3 PUFA derived lipid mediators, protectin D1 and resolvin E1, may act as potent resolution agonists in airway inflammation. The effects of the n-3 PUFA tissue status itself on asthma pathogenesis remains to be further investigated.

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International audience. Lipids, including omega-3 polyunsaturated fatty acids (n-3-PUFAs), modulate brain-intrinsic inflammation during systemic inflammation. The vascular organ of the lamina terminalis (OVLT) is a ...

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