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DisSIRTing on LXR and Cholesterol Metabolism.

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Feige, Jerome N | Auwerx, Johan

Edité par CCSD ; Elsevier -

The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.

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