HBZ impedes the Menin function and up-regulates the transcription of the hTERT gene in leukemic cells

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HBZ impedes the Menin function and up-regulates the transcription of the hTERT gene in leukemic cells

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Borowiak, Malgorzata | Kuhlmann, Anne-Sophie | Girard, Sophie | Gazzolo, Louis | Dodon, Madeleine, Duc

Edité par CCSD ; BioMed Central -

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Langue: en

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HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT).

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BACKGROUND: Activation of telomerase is a critical and late event in tumor progression. Thus, in patients with adult-T cell leukaemia (ATL), an HTLV-1 (Human T cell Leukaemia virus type 1)-associated disease, leukemic cells displa...

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