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HBZ impedes the Menin function and up-regulates the transcription of the hTERT gene in leukemic cells

Archive ouverte | Borowiak, Malgorzata | CCSD

International audience. n.a

HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene

Archive ouverte | Borowiak, Malgorzata | CCSD

International audience

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT).

Archive ouverte | Kuhlmann, Anne-Sophie | CCSD

BACKGROUND: Activation of telomerase is a critical and late event in tumor progression. Thus, in patients with adult-T cell leukaemia (ATL), an HTLV-1 (Human T cell Leukaemia virus type 1)-associated disease, leukemic cells displa...

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