Afficher la couverture 'Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology.. Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology.: FDG PET indices for survival prediction | Hatt, Mathieu' en grand format
/5

0 avis

Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology.. Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology.: FDG PET indices for survival prediction

Archive ouverte

Hatt, Mathieu | Visvikis, Dimitris | Albarghach, Nidal, M. | Tixier, Florent | Pradier, Olivier | Cheze-Le Rest, Catherine

Edité par CCSD ; Springer Verlag (Germany) [1976-....] -

International audience. PURPOSE: (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) image-derived parameters, such as standardized uptake value (SUV), functional tumour length (TL) and tumour volume (TV) or total lesion glycolysis (TLG), may be useful for determining prognosis in patients with oesophageal carcinoma. The objectives of this work were to investigate the prognostic value of these indices in oesophageal cancer patients undergoing combined chemoradiotherapy treatment and the impact of TV delineation strategies. METHODS: A total of 45 patients were retrospectively analysed. Tumours were delineated on pretreatment (18)F-FDG scans using adaptive threshold and automatic (fuzzy locally adaptive Bayesian, FLAB) methodologies. The maximum standardized uptake value (SUV(max)), SUV(peak), SUV(mean), TL, TV and TLG were computed. The prognostic value of each parameter for overall survival was investigated using Kaplan-Meier and Cox regression models for univariate and multivariate analyses, respectively. RESULTS: Large differences were observed between methodologies (from -140 to +50% for TV). SUV measurements were not significant prognostic factors for overall survival, whereas TV, TL and TLG were, irrespective of the segmentation strategy. After multivariate analysis including standard tumour staging, only TV (p < 0.002) and TL (p = 0.042) determined using FLAB were independent prognostic factors. CONCLUSION: Whereas no SUV measurement was a significant prognostic factor, TV, TL and TLG were significant prognostic factors for overall survival, irrespective of the delineation methodology. Only functional TV and TL derived using FLAB were independent prognostic factors, highlighting the need for accurate and robust PET tumour delineation tools for oncology applications.

Suggestions

Du même auteur

Reproducibility of 18F-FDG and 3'-deoxy-3'-18F-fluorothymidine PET tumor volume measurements.. : PET volume determination reproducibility

Archive ouverte | Hatt, Mathieu | CCSD

International audience. The objective of this study was to establish the repeatability and reproducibility limits of several volume-related PET image-derived indices-namely tumor volume (TV), mean standardized uptak...

Intratumor heterogeneity characterized by textural features on baseline 18F-FDG PET images predicts response to concomitant radiochemotherapy in esophageal cancer.

Archive ouverte | Tixier, Florent | CCSD

International audience. UNLABELLED: (18)F-FDG PET is often used in clinical routine for diagnosis, staging, and response to therapy assessment or prediction. The standardized uptake value (SUV) in the primary or reg...

Quantification of intra-tumor 18F-FDG PET tracer uptake heterogeneity through textural features analysis: Which minimum functional tumor volume to consider?

Archive ouverte | Hatt, Mathieu | CCSD

International audience. Intra-tumor uptake heterogeneity in PET has been associated with patient outcome in several cancer models. Amongst the proposed methods for its quantification, textural features (TF) analysis...

Chargement des enrichissements...