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HIV-2 genomic RNA accumulates in stress granules in the absence of active translation

Archive ouverte | Soto-Rifo, Ricardo | CCSD

International audience. During the post-transcriptional events of the HIV-2 replication cycle, the full-length unspliced genomic RNA (gRNA) is first used as an mRNA to synthesize Gag and Gag-Pol proteins and then pa...

Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation.

Archive ouverte | Soto-Rifo, Ricardo | CCSD

International audience. The 5'-untranslated region (5'-UTR) of the genomic RNA of human immunodeficiency viruses type-1 (HIV-1) and type-2 (HIV-2) is composed of highly structured RNA motifs essential for viral repl...

miRNA repression of translation in vitro takes place during 43S ribosomal scanning.

Archive ouverte | Ricci, Emiliano P | CCSD

International audience. microRNAs (miRNAs) regulate gene expression at multiple levels by repressing translation, stimulating deadenylation and inducing the premature decay of target messenger RNAs (mRNAs). Although...

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