Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

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Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

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Edité par CCSD ; American Society of Hematology -

International audience. Key Points Bortezomib induces the degradation of FLT3-ITD through an autophagy-dependent mechanism that contributes to cell death. This finding provides a mechanism-based rationale for the study of proteasome inhibitors in FLT3-ITD–mutant acute myeloid leukemia.

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